Genomics of Gene Expression

customLogoAna Conesa will attend as invited speaker to the International Workshop “Algorithmics, Bioinformatics and Statistics for NGS data analysis“.

The workshop is due to take place in Paris at the Curie Institute from the 22nd to the 23rd of June 2015.

Ana Conesa will present her current research work which takes place at the University of Florida and at the Principe Felipe Center in Valencia (Spain).

Title of the talk

“Integration of multi-omics data to study B-cell differentiation: experimental design and analysis issues”


Next generation sequencing has speed up genome analysis and brought omics research closer to many organisms and biological scenarios. Today an increasing number of research projects propose the combined use of different omics platforms to investigate diverse aspects of genome functioning. These proposals ideally seek to provide complementary sources of molecular information that eventually can be put together to obtain systems biology models of biological processes. Hence, it is not rare anymore to find experimental designs involving the collection of genome, transcriptome, epigenome and even metabolome data on a particular system. However, standard methodologies for the integration of diverse omics data types are not yet ready and researchers frequently face post-experiment question on how to combine data of different nature, variability, and significance into an analysis routine that sheds more light than the analysis of individual datasets separately. In the STATegra we have set out to address these questions using a mouse B-cell differentiation system as model for integrative multi-omics analysis.  We have generated up to 7 different omics measurements that go from chromatin features, through gene expression, to the cellular metabolism.  We will show how to investigate and assess differences in the nature of the data provided by the different omics technologies. We propose different integrative methods to study the dynamics of cell differentiation and to study the regulatory programs that control different stages of the process. Finally I will demonstrate some of the software tools develop by STATegra that are available to the scientific community to analyze multi-omics data.

The workshop will cover both methodological issues of NGS data analysis and biological questions that can be answered through the analysis of high throughput sequencing datasets. Planned invited speakers include computational scientists, bioinformaticians, molecular biologists and clinicians working with NGS data.

Additional information about the workshop: